Background:

This gene encodes the beta subunit of the soluble guanylate cyclase (sGC), which catalyzes the conversion of GTP (guanosine triphosphate) to cGMP (cyclic guanosine monophosphate). The encoded protein contains an HNOX domain, which serves as a receptor for ligands such as nitric oxide, oxygen and nitrovasodilator drugs. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]

Applications:

ELISA, IHC

Name of antibody:

GUCY1B1

Immunogen:

Fusion protein of human GUCY1B1

Full name:

guanylate cyclase 1 soluble subunit beta 1

Synonyms:

GUCB3; GC-SB3; GUC1B3; GUCSB3; GUCY1B3; GC-S-beta-1

SwissProt:

Q02153

IHC positive control:

Human breast cancer

IHC Recommend dilution:

150-300