Background:

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. The protein encoded is a replication-independent histone that is a member of the histone H1 family. This gene contains introns, unlike most histone genes. The related mouse gene is expressed only in oocytes. [provided by RefSeq, Oct 2015]

Applications:

ELISA, IHC

Name of antibody:

H1-8

Immunogen:

Synthetic peptide of human H1-8

Full name:

H1.8 linker histone

Synonyms:

H1.8; H1oo; osH1; H1FOO

SwissProt:

Q8IZA3

IHC positive control:

Human tonsil and Human esophagus cancer

IHC Recommend dilution:

30-150