Background:

HACE1 (HECT domain and ankyrin repeat containing, E3 ubiquitin protein ligase 1), also known as KIAA1320, is a 909 amino acid protein that localizes to both the cytoplasm and the endoplasmic reticulum and contains one HECT domain and six ANK repeats. Expressed in kidney, heart and brain, HACE1 functions as an E3 ubiquitin-protein ligase that interacts with the proteasome and is thought to play a role in protein degradation. HACE1 is downregulated in Wilms tumor, suggesting a possible role in tumor suppression.

Applications:

ELISA, IHC

Name of antibody:

HACE1

Immunogen:

Synthetic peptide of human HACE1

Full name:

HECT domain and ankyrin repeat containing E3 ubiquitin protein ligase 1

SwissProt:

Q8IYU2

ELISA Recommended dilution:

2000-5000

IHC positive control:

Human colon cancer and Human ovarian cancer

IHC Recommend dilution:

100-200