Background:

This gene encodes the alpha subunit of the mitochondrial trifunctional protein, which catalyzes the last three steps of mitochondrial beta-oxidation of long chain fatty acids. The mitochondrial membrane-bound heterocomplex is composed of four alpha and four beta subunits, with the alpha subunit catalyzing the 3-hydroxyacyl-CoA dehydrogenase and enoyl-CoA hydratase activities. Mutations in this gene result in trifunctional protein deficiency or LCHAD deficiency. The genes of the alpha and beta subunits of the mitochondrial trifunctional protein are located adjacent to each other in the human genome in a head-to-head orientation.

Applications:

ELISA, WB, IHC

Name of antibody:

HADHA

Immunogen:

Fusion protein of human HADHA

Full name:

hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit

Synonyms:

GBP; ECHA; HADH; LCEH; MTPA; LCHAD; TP-ALPHA

SwissProt:

P40939

ELISA Recommended dilution:

5000-10000

IHC positive control:

Human ovarian cancer

IHC Recommend dilution:

25-100

WB Predicted band size:

83 kDa

WB Positive control:

A431，HEPG2，Jurkat and 293T cell lysates

WB Recommended dilution:

500-2000