Background:

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. N-terminal part of this PTP contains two tandem Src homolog (SH2) domains, which act as protein phospho-tyrosine binding domains, and mediate the interaction of this PTP with its substrates.

Applications:

WB

Name of antibody:

PTPN6(Phospho-Tyr564)

Immunogen:

Peptide sequence around phosphorylation site of tyrosine 564(D-V-Y(p)-E-N) derived from Human SHP-1.

Full name:

protein tyrosine phosphatase, non-receptor type 6

Synonyms：

HCP; HCPH; SHP1; SHP-1; HPTP1C; PTP-1C; SHP-1L; SH-PTP1

SwissProt:

P29350

WB Predicted band size:

68 kDa

WB Positive control:

COS7 cells lysates treated with EGF

WB Recommended dilution:

500-1000