Background:

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus represents a receptor-type PTP. This PTP has been shown to dephosphorylate and activate Src family tyrosine kinases, and is implicated in the regulation of integrin signaling, cell adhesion and proliferation. Three alternatively spliced variants of this gene, which encode two distinct isoforms, have been reported.

Applications:

ELISA, WB

Name of antibody:

PTPRA

Immunogen:

Fusion protein of human PTPRA

Full name:

protein tyrosine phosphatase, receptor type A

Synonyms:

LRP; HLPR; PTPA; HEPTP; HPTPA; RPTPA; PTPRL2; HPTPalpha; R-PTP-alpha

SwissProt:

P18433

ELISA Recommended dilution:

5000-10000

WB Predicted band size:

91 kDa

WB Positive control:

Mouse brain tissue lysate

WB Recommended dilution:

500-2000