Background:

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and two tandem intracytoplasmic catalytic domains, and thus represents a receptor-type PTP. The extracellular region of this PTP contains a carbonic anhydrase-like (CAH) domain, which is also found in the extracellular region of PTPRBETA/ZETA. This gene is located in a chromosomal region that is frequently deleted in renal cell carcinoma and lung carcinoma, thus is thought to be a candidate tumor suppressor gene.

Applications:

ELISA, IHC

Name of antibody:

PTPRG

Immunogen:

Synthetic peptide of human PTPRG

Full name:

protein tyrosine phosphatase, receptor type, G

Synonyms:

PTPG; HPTPG; RPTPG; R-PTP-GAMMA

SwissProt:

P23470

ELISA Recommended dilution:

5000-10000

IHC positive control:

Human tonsil and human cervical cancer

IHC Recommend dilution:

25-100