Background:

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes, including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region containing five fibronectin type III repeats, a single transmembrane region, and a single intracytoplasmic catalytic domain, and thus represents a receptor-type PTP. This protein is present in all hematopoietic lineages, and was shown to negatively regulate T cell receptor signaling possibly through interfering with the phosphorylation of Phospholipase C Gamma 1 and Linker for Activation of T Cells. This protein can also dephosphorylate the PDGF beta receptor, and may be involved in UV-induced signal transduction. Multiple transcript variants encoding different isoforms have been found for this gene.

Applications:

ELISA, IHC

Name of antibody:

PTPRJ

Immunogen:

Synthetic peptide of human PTPRJ

Full name:

Protein tyrosine phosphatase, receptor type, J

Synonyms：

DEP1, SCC1, CD148, HPTPeta, R-PTP-ETA

SwissProt:

Q12913

ELISA Recommended dilution:

1000-5000

IHC positive control:

Human breast cancer and Human liver cancer

IHC Recommend dilution:

25-100