Background:

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and two tandem catalytic domains, and thus represents a receptor-type PTP. The extracellular region contains a meprin-A5 antigen-PTP mu (MAM) domain, an Ig-like domain and four fibronectin type III-like repeats. This PTP has been shown to mediate cell-cell aggregation through the interaction with another molecule of this PTP on an adjacent cell. This PTP can interact with scaffolding protein RACK1/GNB2L1, which may be necessary for the downstream signaling in response to cell-cell adhesion. Alternative splicing results in multiple transcripts encoding distinct isoforms.

Applications:

ELISA, IHC

Name of antibody:

PTPRM

Immunogen:

Synthetic peptide of human PTPRM

Full name:

Protein tyrosine phosphatase, receptor type, M

Synonyms：

RPTPM, RPTPU, PTPRL1, hR-PTPu, R-PTP-MU

SwissProt:

P28827

ELISA Recommended dilution:

2000-10000

IHC positive control:

Human breast cancer and Human lung cancer

IHC Recommend dilution:

50-200