Background:

This gene encodes a human guanine nucleotide exchange factor. It transduces signals from CRK by binding the SH3 domain of CRK, and activating several members of the Ras family of GTPases. This signaling cascade that may be involved in apoptosis, integrin-mediated signal transduction, and cell transformation. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some variants has not been determined.

Applications:

ELISA, IHC

Name of antibody:

RAPGEF1

Immunogen:

Synthetic peptide of human RAPGEF1

Full name:

Rap guanine nucleotide exchange factor 1

Synonyms:

C3G; GRF2

SwissProt:

Q13905

ELISA Recommended dilution:

5000-10000

IHC positive control:

Human tonsil

IHC Recommend dilution:

25-100