Background:

This gene encodes a member of the GAP1 family of GTPase-activating proteins that suppresses the Ras/mitogen-activated protein kinase pathway in response to Ca(2+). Stimuli that increase intracellular Ca(2+) levels result in the translocation of this protein to the plasma membrane, where it activates Ras GTPase activity. Consequently, Ras is converted from the active GTP-bound state to the inactive GDP-bound state and no longer activates downstream pathways that regulate gene expression, cell growth, and differentiation. Multiple transcript variants encoding different isoforms have been found for this gene. [

Applications:

ELISA, IHC

Name of antibody:

RASA4

Immunogen:

Fusion protein of human RASA4

Full name:

RAS p21 protein activator 4

Synonyms：

GAPL; CAPRI

SwissProt:

O43374

ELISA Recommended dilution:

1000-2000

IHC positive control:

Human liver cancer and human esophagus cancer

IHC Recommend dilution:

10-50