Background:

This gene encodes a protein similar to the RAS effector proteins. Loss or altered expression of this gene has been associated with the pathogenesis of a variety of cancers, which suggests the tumor suppressor function of this gene. The inactivation of this gene was found to be correlated with the hypermethylation of its CpG-island promoter region. The encoded protein was found to interact with DNA repair protein XPA. The protein was also shown to inhibit the accumulation of cyclin D1, and thus induce cell cycle arrest. Several alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.

Applications:

ELISA, IHC

Name of antibody:

RASSF1

Immunogen:

Fusion protein of human RASSF1

Full name:

Ras association (RalGDS/AF-6) domain family member 1

Synonyms：

123F2; RDA32; NORE2A; RASSF1A; REH3P21

SwissProt:

Q9NS23

ELISA Recommended dilution:

2000-5000

IHC positive control:

Human brain

IHC Recommend dilution:

20-100