Background:

The protein encoded by this gene is a negative regulator of the cell cycle and was the first tumor suppressor gene found. The encoded protein also stabilizes constitutive heterochromatin to maintain the overall chromatin structure. The active, hypophosphorylated form of the protein binds transcription factor E2F1. Defects in this gene are a cause of childhood cancer retinoblastoma (RB), bladder cancer, and osteogenic sarcoma.

Applications:

WB

Name of antibody:

RB1(Ab-608)

Immunogen:

Synthesized non-phosphopeptide derived from human Retinoblastoma around the phosphorylation site of serine 608 (Y-L-S(p)-P-V).

Full name:

retinoblastoma 1

Synonyms：

RB; pRb; OSRC; pp110; p105-Rb; PPP1R130

SwissProt:

P06400

WB Predicted band size:

106 kDa

WB Positive control:

Jurkat cells treated with PMA (125ng/ml, 30mins) lysate

WB Recommended dilution:

500-3000