Background:

The protein encoded by this gene is a ubiquitously expressed nuclear protein. It is found among several proteins that bind directly to retinoblastoma protein, which regulates cell proliferation. This protein complexes with transcriptional co-repressor CTBP. It is also associated with BRCA1 and is thought to modulate the functions of BRCA1 in transcriptional regulation, DNA repair, and/or cell cycle checkpoint control. It is suggested that this gene may itself be a tumor suppressor acting in the same pathway as BRCA1. Three transcript variants encoding two different isoforms have been found for this gene. More transcript variants exist, but their full-length natures have not been determined.

Applications:

ELISA, IHC

Name of antibody:

RBBP8

Immunogen:

Fusion protein of human RBBP8

Full name:

retinoblastoma binding protein 8

Synonyms：

RIM; COM1; CTIP; JWDS; SAE2; SCKL2

SwissProt:

Q99708

ELISA Recommended dilution:

2000-10000

IHC positive control:

Human thyroid cancer and human gastric cancer

IHC Recommend dilution:

100-300