Background:

The Fox-1 family of RNA-binding proteins is evolutionarily conserved, and regulates tissue-specific alternative splicing in metazoa. Fox-1 recognizes a (U)GCAUG stretch in regulated exons or in flanking introns. The protein binds to the C-terminus of ataxin-2 and may contribute to the restricted pathology of spinocerebellar ataxia type 2 (SCA2). Ataxin-2 is the product of the SCA2 gene which causes familial neurodegenerative diseases. Fox-1 and ataxin-2 are both localized in the trans-Golgi network. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Applications:

ELISA, IHC

Name of antibody:

RBFOX1

Immunogen:

Synthetic peptide of human RBFOX1

Full name:

RNA binding fox-1 homolog 1

Synonyms:

2BP1; FOX1; A2BP1; FOX-1; HRNBP1

SwissProt:

Q9NWB1

ELISA Recommended dilution:

1000-2000

IHC positive control:

Human liver cancer

IHC Recommend dilution:

10-50