Background:

The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein is a ligand for the FN14/TWEAKR receptor. This cytokine has overlapping signaling functions with TNF, but displays a much wider tissue distribution. This cytokine, which exists in both membrane-bound and secreted forms, can induce apoptosis via multiple pathways of cell death in a cell type-specific manner. This cytokine is also found to promote proliferation and migration of endothelial cells, and thus acts as a regulator of angiogenesis.

Applications:

WB, IHC, IF

Name of antibody:

TNFSF12

Immunogen:

Synthesized peptide derived from internal of human TNF12.

Full name:

tumor necrosis factor (ligand) superfamily, member 12

Synonyms：

APO3L; DR3LG; TWEAK

SwissProt:

O43508

IHC positive control:

Human brain tissue

IHC Recommend dilution:

50-100

WB Predicted band size:

27 kDa

WB Positive control:

COLO cells, Huvec cells and 293 cells lysates

WB Recommended dilution:

500-3000

IF positive control:

Hela cells

IF Recommend dilution:

100-500