Background:

This gene encodes a tyrosine kinase that binds Cdc42Hs in its GTP-bound form and inhibits both the intrinsic and GTPase-activating protein (GAP)-stimulated GTPase activity of Cdc42Hs. This binding is mediated by a unique sequence of 47 amino acids C-terminal to an SH3 domain. The protein may be involved in a regulatory mechanism that sustains the GTP-bound active form of Cdc42Hs and which is directly linked to a tyrosine phosphorylation signal transduction pathway. Several alternatively spliced transcript variants have been identified from this gene, but the full-length nature of only two transcript variants has been determined.

Applications:

ELISA, WB, IHC

Name of antibody:

TNK2

Immunogen:

Synthetic peptide of human TNK2

Full name:

tyrosine kinase, non-receptor, 2

Synonyms：

ACK, ACK1, ACK-1, p21cdc42Hs

SwissProt:

Q07912

ELISA Recommended dilution:

2000-10000

IHC positive control:

Human breast cancer and Human liver cancer

IHC Recommend dilution:

50-200

WB Predicted band size:

119 kDa

WB Positive control:

231 cells

WB Recommended dilution:

1000-5000