Background:

Troponin I (TnI), along with troponin T (TnT) and troponin C (TnC), is one of 3 subunits that form the troponin complex of the thin filaments of striated muscle. TnI is the inhibitory subunit; blocking actin-myosin interactions and thereby mediating striated muscle relaxation. The TnI subfamily contains three genes: TnI-skeletal-fast-twitch, TnI-skeletal-slow-twitch, and TnI-cardiac. This gene encodes the TnI-cardiac protein and is exclusively expressed in cardiac muscle tissues. Mutations in this gene cause familial hypertrophic cardiomyopathy type 7 (CMH7) and familial restrictive cardiomyopathy (RCM).

Applications:

WB

Name of antibody:

TNNI3(Phospho-Thr142)

Immunogen:

Peptide sequence around phosphorylation site of Threonine 142 (R-P-T(p)-L-R) derived from Human TNNI3.

Full name:

troponin I type 3 (cardiac)

Synonyms：

CMH7; RCM1; cTnI; CMD2A; TNNC1; CMD1FF

SwissProt:

P19429

WB Predicted band size:

24 kDa

WB Positive control:

Mouse heart tissue lysates

WB Recommended dilution:

500-1000