Background:

Troponin I (TnI), along with troponin T (TnT) and troponin C (TnC), is one of 3 subunits that form the troponin complex of the thin filaments of striated muscle. TnI is the inhibitory subunit; blocking actin-myosin interactions and thereby mediating striated muscle relaxation. The TnI subfamily contains three genes: TnI-skeletal-fast-twitch, TnI-skeletal-slow-twitch, and TnI-cardiac. This gene encodes the TnI-cardiac protein and is exclusively expressed in cardiac muscle tissues. Mutations in this gene cause familial hypertrophic cardiomyopathy type 7 (CMH7) and familial restrictive cardiomyopathy (RCM).

Applications:

ELISA, WB, IHC

Name of antibody:

TNNI3

Immunogen:

Fusion protein of human TNNI3

Full name:

troponin I type 3 (cardiac)

Synonyms：

CMH7; RCM1; cTnI; CMD2A; TNNC1; CMD1FF

SwissProt:

P19429

ELISA Recommended dilution:

2000-5000

IHC positive control:

Human thyroid cancer and human breast cancer

IHC Recommend dilution:

25-100

WB Predicted band size:

24 kDa

WB Positive control:

Mouse heart tissue

WB Recommended dilution:

200-1000