Background:

This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This nuclear enzyme is involved in processes such as chromosome condensation, chromatid separation, and the relief of torsional stress that occurs during DNA transcription and replication. It catalyzes the transient breaking and rejoining of two strands of duplex DNA which allows the strands to pass through one another, thus altering the topology of DNA. Two forms of this enzyme exist as likely products of a gene duplication event.

Applications:

WB

Name of antibody:

TOP2A(Phospho-Thr1343)

Immunogen:

Peptide sequence around phosphorylation site of threonine1343(E-K-T(p)-D-D) derived from Human TOP2A.

Full name:

topoisomerase (DNA) II alpha 170kDa

Synonyms：

TOP2; TP2A

SwissProt:

P11388

WB Predicted band size:

174 kDa

WB Positive control:

HepG2 cells lysates treated with Ca2+

WB Recommended dilution:

500-1000