Background:

This gene encodes a member of the p53 family of transcription factors. The functional domains of p53 family proteins include an N-terminal transactivation domain, a central DNA-binding domain and an oligomerization domain. Alternative splicing of this gene and the use of alternative promoters results in multiple transcript variants encoding different isoforms that vary in their functional properties. These isoforms function during skin development and maintenance,  stem/progenitor cell regulation, heart development and premature aging. Some isoforms have been found to protect the germline by eliminating oocytes or testicular germ cells that have suffered DNA damage. Mutations in this gene are associated with ectodermal dysplasia, and cleft lip/palate syndrome 3 (EEC3); split-hand/foot malformation 4 (SHFM4); ankyloblepharon-ectodermal defects-cleft lip/palate;  syndrome (acro-dermato-ungual-lacrimal-tooth); limb-mammary syndrome; Rap-Hodgkin syndrome (RHS); and orofacial cleft 8.

Applications:

ELISA, WB, IHC

Name of antibody:

TP63

Immunogen:

Fusion protein of human TP63

Full name:

tumor protein p63

Synonyms:

AIS; KET; LMS; NBP; RHS; p40; p51; p63; EEC3; OFC8; p73H; p73L; SHFM4; TP53L; TP73L; p53CP; TP53CP; B(p51A); B(p51B)

SwissProt:

Q9H3D4

ELISA Recommended dilution:

5000-10000

IHC positive control:

Human lung cancer

IHC Recommend dilution:

50-200

WB Predicted band size:

77 kDa

WB Positive control:

PC3 and Jurkat cell lysates

WB Recommended dilution:

500-2000