Background:

The protein encoded by this gene is a member of the TNF receptor (TNFR) associated factor (TRAF) protein family. TRAF proteins associate with, and mediate the signal transduction from various receptors of the TNFR superfamily. This protein and TRAF2 form a heterodimeric complex, which is required for TNF-alpha-mediated activation of MAPK8/JNK and NF-kappaB. The protein complex formed by this protein and TRAF2 also interacts with inhibitor-of-apoptosis proteins (IAPs), and thus mediates the anti-apoptotic signals from TNF receptors. The expression of this protein can be induced by Epstein-Barr virus (EBV). EBV infection membrane protein 1 (LMP1) is found to interact with this and other TRAF proteins; this interaction is thought to link LMP1-mediated B lymphocyte transformation to the signal transduction from TNFR family receptors.

Applications:

ELISA, WB, IHC

Name of antibody:

TRAF1

Immunogen:

Fusion protein of human TRAF1

Full name:

TNF receptor-associated factor 1

Synonyms：

EBI6; MGC:10353

SwissProt:

Q13077

ELISA Recommended dilution:

1000-2000

IHC positive control:

Human colon cancer and human cervical cancer

IHC Recommend dilution:

15-50

WB Predicted band size:

46 kDa

WB Positive control:

Human lymphoma tissue

WB Recommended dilution:

200-1000