Background:

This gene encodes a protein involved in regulating responses to cytokines by members of the Rel/NF-kappaB transcription factor family. These factors play a central role in innate immunity in response to pathogens, inflammatory signals and stress. This gene product interacts with TRAF proteins (tumor necrosis factor receptor-associated factors) and either I-kappaB kinase or MAP kinase to activate either NF-kappaB or Jun kinase. Several alternative transcripts encoding different isoforms have been identified. Another transcript, which does not encode a protein and is transcribed in the opposite orientation, has been identified. Overexpression of this transcript has been shown to reduce expression of at least one of the protein encoding transcripts, suggesting it has a regulatory role in the expression of this gene.

Applications:

ELISA, WB, IHC

Name of antibody:

TRAF3IP2

Immunogen:

Fusion protein of human TRAF3IP2

Full name:

TRAF3 interacting protein 2

Synonyms：

ACT1; CIKS; C6orf2; C6orf4; C6orf5; C6orf6; PSORS13

SwissProt:

O43734

ELISA Recommended dilution:

1000-2000

IHC positive control:

Human colon cancer and human liver cancer

IHC Recommend dilution:

25-100

WB Predicted band size:

65 kDa

WB Positive control:

Jurkat cells

WB Recommended dilution:

200-1000