Background:

The protein encoded by this gene is a member of the TNF receptor associated factor (TRAF) protein family. TRAF proteins associate with, and mediate the signal transduction from, members of the TNF receptor (TNFR) superfamily. This protein participates in the signal transduction of CD40, a TNFR family member important for the activation of the immune response. This protein is found to be a critical component of the lymphotoxin-beta receptor (LTbetaR) signaling complex, which induces NF-kappaB activation and cell death initiated by LTbeta ligation. Epstein-Barr virus encoded latent infection membrane protein-1 (LMP1) can interact with this and several other members of the TRAF family, which may be essential for the oncogenic effects of LMP1. Several alternatively spliced transcript variants encoding three distinct isoforms have been reported.

Applications:

ELISA, WB, IHC

Name of antibody:

TRAF3

Immunogen:

Synthetic peptide of human TRAF3

Full name:

TNF receptor-associated factor 3

Synonyms：

CAP1, LAP1, CAP-1, CRAF1, IIAE5, CD40bp

SwissProt:

Q13114

ELISA Recommended dilution:

1000-5000

IHC positive control:

Human tonsil

IHC Recommend dilution:

25-100

WB Predicted band size:

64 kDa

WB Positive control:

Mouse kidney tissue

WB Recommended dilution:

200-1000