Background:

The melanoma-associated antigen (MAGE) family consists of a number of antigens recognized by cytotoxic T lymphocytes. The MAGE genes were initially isolated from different kinds of tumors and, based on their virtually exclusive tumor-specific expression in ***** tissues, they have been used as targets for cancer immunotherapy. MAGE genes encode for tumor-rejection antigens that are expressed in tumors of different histologic types and in normal testis and placenta. MAGE-B5 (melanoma-associated antigen B5), also known as CT3.3 (cancer/testis antigen 3.3), is a 275 amino acid protein that contains one MAGE domain and is expressed in testis. The gene encoding MAGE-B5 maps to human chromosome X, which consists of about 153 million base pairs and nearly 1,000 genes. Color blindness, hemophilia and Duchenne muscular dystrophy are well known X chromosome-linked conditions which affect males more frequently, as males carry a single X chromosome.

Applications:

ELISA, IHC

Name of antibody:

MAGEB5

Immunogen:

Synthetic peptide of human MAGEB5

Full name:

MAGE family member B5

Synonyms:

CT3.3; MAGE-B5

SwissProt:

Q9BZ81

ELISA Recommended dilution:

5000-10000

IHC positive control:

Human thyroid cancer and human liver cancer

IHC Recommend dilution:

20-100