Background:

The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is known to play a critical role in mitogen growth factor signal transduction. It phosphorylates and thus activates MAPK1/ERK2 and MAPK2/ERK3. The activation of this kinase itself is dependent on the Ser/Thr phosphorylation by MAP kinase kinase kinases. Mutations in this gene cause cardiofaciocutaneous syndrome (CFC syndrome), a disease characterized by heart defects, mental retardation, and distinctive facial features similar to those found in Noonan syndrome. The inhibition or degradation of this kinase is also found to be involved in the pathogenesis of Yersinia and anthrax. A pseudogene, which is located on chromosome 7, has been identified for this gene.

Applications:

ELISA, WB, IHC

Name of antibody:

MAP2K2

Immunogen:

Synthetic peptide of human MAP2K2

Full name:

mitogen-activated protein kinase kinase 2

Synonyms:

MEK2, MKK2, MAPKK2, PRKMK2

SwissProt:

P36507

IHC positive control:

Human gastric cancer and human ovarian cancer

IHC Recommend dilution:

100-300

WB Predicted band size:

44 kDa

WB Positive control:

Hela, NIH/3T3 and Jurkat cells

WB Recommended dilution:

1000-5000