Background:

The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is activated by mitogenic and environmental stress, and participates in the MAP kinase-mediated signaling cascade. It phosphorylates and thus activates MAPK14/p38-MAPK. This kinase can be activated by insulin, and is necessary for the expression of glucose transporter.

Applications:

WB, IHC

Name of antibody:

MAP2K3(Phospho-Thr222)

Immunogen:

Peptide sequence around phosphorylation site of threonine 222(A-K-T(p)-M-D) derived from Human MAP2K3 .

Full name:

mitogen-activated protein kinase kinase 3

Synonyms：

MEK3; MKK3; MAPKK3; PRKMK3; SAPKK2; SAPKK-2

SwissProt:

P46734

IHC positive control:

Human brain tissue

IHC Recommend dilution:

50-100

WB Predicted band size:

39 kDa

WB Positive control:

Jurkat cells lysates treated with serum

WB Recommended dilution:

500-1000