Background:

The protein encoded by this gene is a serine/threonine kinase and is part of some signal transduction cascades, including the ERK and JNK kinase pathways as well as the NF-kappa-B pathway. The encoded protein is activated by autophosphorylation and requires magnesium as a cofactor in phosphorylating other proteins. This protein has E3 ligase activity conferred by a plant homeodomain (PHD) in its N-terminus and phospho-kinase activity conferred by a kinase domain in its C-terminus.

Applications:

WB, IHC

Name of antibody:

MAP3K1(Phospho-Thr1402)

Immunogen:

Peptide sequence around phosphorylation site of threonine 1402(T-G-A(p)-G-F) derived from Human MAP3K1.

Full name:

mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase

Synonyms：

MEKK; MEKK1; SRXY6; MEKK 1; MAPKKK1

SwissProt:

Q13233

IHC positive control:

Human brain tissue

IHC Recommend dilution:

50-100

WB Predicted band size:

164 kDa

WB Positive control:

Jurkat cells lysates

WB Recommended dilution:

500-1000