Background:

This gene was identified by its oncogenic transforming activity in cells. The encoded protein is a member of the serine/threonine protein kinase family. This kinase can activate both the MAP kinase and JNK kinase pathways. This kinase was shown to activate IkappaB kinases, and thus induce the nuclear production of NF-kappaB. This kinase was also found to promote the production of TNF-alpha and IL-2 during T lymphocyte activation. Studies of a similar gene in rat suggested the direct involvement of this kinase in the proteolysis of NF-kappaB1,p105 (NFKB1).

Applications:

IHC

Name of antibody:

MAP3K8(Phospho-Ser400)

Immunogen:

Peptide sequence around phosphorylation site of Serine 400(C-Q-S(p)-L-D) derived from HumanMAP3K8.

Full name:

mitogen-activated protein kinase kinase kinase 8

Synonyms：

COT; EST; ESTF; TPL2; MEKK8; Tpl-2; c-COT

SwissProt:

P41279

IHC positive control:

Human brain tissue

IHC Recommend dilution:

50-100