Background:

This gene encodes a member of the mitogen-activated protein kinase kinase kinase kinase family. The encoded protein activates key effectors in cell signalling, among them c-Jun. Alternatively spliced transcripts encoding multiple isoforms have been observed for this gene. May play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. Ubiquitously expressed in all tissues examined, with high levels in heart, brain, placenta, skeletal muscle, kidney and pancreas and lower levels in lung and liver.

Applications:

ELISA, WB, IHC

Name of antibody:

MAP4K3

Immunogen:

Fusion protein of human MAP4K3

Full name:

Mitogen-activated protein kinase kinase kinase kinase 3

Synonyms：

GLK; MEKKK3; MEKKK 3; MAPKKKK3; RAB8IPL1

SwissProt:

Q8IVH8

ELISA Recommended dilution:

2000-5000

IHC positive control:

Human thyroid cancer

IHC Recommend dilution:

25-100

WB Predicted band size:

101 kDa

WB Positive control:

Mouse heart tissue

WB Recommended dilution:

500-2000