Background:

Responds to activation by environmental stress, pro-inflammatory cytokines and lipopolysaccharide (LPS) by phosphorylating a number of transcription factors, such as ELK1 and ATF2 and several downstream kinases, such as MAPKAPK2 and MAPKAPK5. Plays a critical role in the production of some cytokines, for example IL-6. May play a role in stabilization of EPO mRNA during hypoxic stress. Isoform Mxi2 activation is stimulated by mitogens and oxidative stress and only poorly phosphorylates ELK1 and ATF2. Isoform Exip may play a role in the early onset of apoptosis.

Applications:

WB, IHC

Name of antibody:

MAPK14 (Phospho-Thr180)

Immunogen:

Synthetic peptide of human MAPK14 (Phospho-Thr180)

Full name:

mitogen-activated protein kinase 14 (Phospho-Thr180)

Synonyms：

RP1-179N16.5; CSBP; CSBP1; CSBP2; CSPB1; EXIP; Mxi2; PRKM14; PRKM15; RK; SAPK2A; p38; P38alpha

SwissProt:

Q16539

IHC positive control:

Human breast carcinoma

IHC Recommend dilution:

50-100

WB Predicted band size:

43 kDa

WB Positive control:

HT29 cells untreated or treated with UV

WB Recommended dilution:

500-1000