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  • 產品名稱:NFKBIE抗原(重組蛋白)

  • 產品型號:1mg
  • 產品廠商:通蔚生物
  • 產品價格:3580
  • 產品庫存:35
  • 產品文檔:
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我司專業經銷生命科學領域NFKBIE抗原(重組蛋白),有著豐富服務經驗和深厚專業背景的團隊為您提供技術服務和支持,各種標本、種屬、具體指標齊全,檢測范圍以及試劑盒內容及其配制,我們努力的腳步不會就此停息,我們的成績離不開廣大新老客戶的支持與厚愛,在未來的一年里,我們將更加努力,用上等的產品與誠摯的服務回饋廣大用戶!
詳情介紹:

中文名稱: NFKBIE抗原(重組蛋白)

英文名稱: NFKBIE Antigen (Recombinant Protein)

儲     存:  冷凍(-20℃)

相關類別: 抗原

概     述

Fusion protein corresponding to a region derived from 63-423 amino acids of human NFKBIE

技術規格

Full name:

Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon

Synonyms:

IKBE

Swissprot:

O00221

Gene Accession:

BC011676

Purity:

>85%, as determined by Coomassie blue stained SDS-PAGE

Expression system:

Escherichia coli

Tags:

His tag C-Terminus, GST tag N-Terminus

Background:

The protein encoded by this gene binds to components of NF-kappa-B, trapping the complex in the cytoplasm and preventing it from activating genes in the nucleus. Phosphorylation of the encoded protein targets it for destruction by the ubiquitin pathway, which activates NF-kappa-B by making it available to translocate to the nucleus. NFKBIE protein expression is up-regulated following NF-κB activation and during myelopoiesis. NFKBIE is able to inhibit NF-κB-directed transactivation via cytoplasmic retention of REL proteins. NFKB1 or NFKB2 is bound to REL, RELA, or RELB to form the NF-κB transcription factor complex. The NF-κB complex is inhibited by I-kappa-B proteins (NFKBIA or NFKBIB), which inactivate NF-kappa-B by trapping it in the cytoplasm.





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