Background:

Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. These enzymes are involved in cellular defense against toxic, carcinogenic, and pharmacologically active electrophilic compounds. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. This gene encodes a glutathione S-tranferase belonging to the alpha class genes that are located in a cluster mapped to chromosome 6. Genes of the alpha class are highly related and encode enzymes with glutathione peroxidase activity. However, during evolution, this alpha class gene diverged accumulating mutations in the active site that resulted in differences in substrate specificity and catalytic activity.

Applications:

ELISA, WB, IHC

Name of antibody:

GSTA3

Immunogen:

Fusion protein of human GSTA3

Full name:

glutathione S-transferase alpha 3

Synonyms：

GTA3; GSTA3-3

SwissProt:

Q16772

ELISA Recommended dilution:

2000-5000

IHC positive control:

Human colon cancer and human liver cancer

IHC Recommend dilution:

50-200

WB Predicted band size:

25 kDa

WB Positive control:

Human testis tissue and HepG2 cells

WB Recommended dilution:

500-2000