Background:

Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. This gene encodes a glutathione S-transferase that belongs to the mu class. The mu class of enzymes functions in the detoxification of electrophilic compounds, including carcinogens, therapeutic drugs, environmental toxins and products of oxidative stress, by conjugation with glutathione. The genes encoding the mu class of enzymes are organized in a gene cluster on chromosome 1p13.3 and are known to be highly polymorphic. These genetic variations can change an individual's susceptibility to carcinogens and toxins as well as affect the toxicity and efficacy of certain drugs. Diversification of these genes has occurred in regions encoding substrate-binding domains, as well as in tissue expression patterns, to accommodate an increasing number of foreign compounds. Multiple transcript variants, each encoding a distinct protein isoform, have been identified.

Applications:

ELISA, WB, IHC

Name of antibody:

GSTM4

Immunogen:

Full length fusion protein

Full name:

glutathione S-transferase mu 4

Synonyms：

GTM4; GSTM4-4

SwissProt:

Q03013

ELISA Recommended dilution:

5000-10000

IHC positive control:

Human thyroid cancer and human lung cancer

IHC Recommend dilution:

10-50

WB Predicted band size:

26 kDa

WB Positive control:

Mouse liver tissue，Mouse lung tissue

WB Recommended dilution:

200-1000