Background:

This gene encodes a GTPase that triggers back-translocation of the elongating ribosome during mitochondrial protein synthesis. The protein contains a highly conserved C-terminal domain not found in other GTPases that facilitates tRNA binding. The encoded protein is thought to prevent misincorporation of amino acids in stressful, suboptimal conditions. An allelic variant in this gene has been associated with early infantile epileptic encephalopathy-40. Alternative splicing results in multiple transcript variants.

Applications:

IHC

Name of antibody:

GUF1

Immunogen:

Synthesized peptide derived from internal of human GUF1.

Full name:

GUF1 homolog, GTPase

Synonyms:

EF4; EF-4; EIEE40

SwissProt:

Q8N442

IHC positive control:

Human colon carcinoma tissue

IHC Recommend dilution:

50-100