Background:

Cytolytic T lymphocytes (CTL) and natural killer (NK) cells share the remarkable ability to recognize, bind, and lyse specific target cells. They are thought to protect their host by lysing cells bearing on their surface 'nonself' antigens, usually peptides or proteins resulting from infection by intracellular pathogens. The protein encoded by this gene is crucial for the rapid induction of target cell apoptosis by CTL in cell-mediated immune response.

Applications:

ELISA, IHC

Name of antibody:

GZMB

Immunogen:

Fusion protein of human GZMB

Full name:

granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)

Synonyms：

HLP; CCPI; CGL1; CSPB; SECT; CGL-1; CSP-B; CTLA1; CTSGL1

SwissProt:

P10144

ELISA Recommended dilution:

2000-5000

IHC positive control:

Human thyroid cancer

IHC Recommend dilution:

25-100