Background:

Histones are basic nuclear proteins responsible for nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H1 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6. [provided by RefSeq, Aug 2015]

Applications:

ELISA, IHC

Name of antibody:

H1-3

Immunogen:

Synthetic peptide of human H1-3

Full name:

H1.3 linker histone, cluster member

Synonyms:

H1D; H1.3; H1F3; H1s-2; HIST1H1D

SwissProt:

P16402

IHC positive control:

Human ovarian cancer and Human colorectal cancer

IHC Recommend dilution:

50-300