Background:

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H2A family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the histone microcluster on chromosome 6p21.33. [provided by RefSeq, Aug 2015]

Applications:

ELISA, WB, IHC

Name of antibody:

H2AC12

Immunogen:

Fusion protein of human H2AC12

Full name:

H2A clustered histone 12

Synonyms:

H2AH; H2A/S; H2AFALii; HIST1H2AH; dJ86C11.1

SwissProt:

Q96KK5

IHC positive control:

Human colon cancer and Human liver cancer

IHC Recommend dilution:

50-200

WB Predicted band size:

14 kDa

WB Positive control:

Mouse liver tissue, HepG2, 293T, Hela, Raji, A375 and K562 cells

WB Recommended dilution:

500-2000