Background:

The protein encoded by this gene belongs to the basic helix-loop-helix family of transcription factors. This gene product is one of two closely related family members, the HAND proteins, which are asymmetrically expressed in the developing ventricular chambers and play an essential role in cardiac morphogenesis. Working in a complementary fashion, they function in the formation of the right ventricle and aortic arch arteries, implicating them as mediators of congenital heart disease. In addition, it has been suggested that this transcription factor may be required for early trophoblast differentiation.

Applications:

ELISA, IHC

Name of antibody:

HAND1

Immunogen:

Synthetic peptide of human HAND1

Full name:

heart and neural crest derivatives expressed 1

Synonyms:

Hxt; eHand; Thing1; bHLHa27

SwissProt:

O96004

ELISA Recommended dilution:

5000-10000

IHC positive control:

Human esophagus cancer and human thyroid cancer

IHC Recommend dilution:

20-100