Background:

The protein encoded by this gene belongs to the immunoglobulin superfamily, and TIM family of proteins. CD4-positive T helper lymphocytes can be divided into types 1 (Th1) and 2 (Th2) on the basis of their cytokine secretion patterns. Th1 cells are involved in cell-mediated immunity to intracellular pathogens and delayed-type hypersensitivity reactions, whereas, Th2 cells are involved in the control of extracellular helminthic infections and the promotion of atopic and allergic diseases. This protein is a Th1-specific cell surface protein that regulates macrophage activation, and inhibits Th1-mediated auto- and alloimmune responses, and promotes immunological tolerance.

Applications:

ELISA, IHC

Name of antibody:

HAVCR2

Immunogen:

Synthetic peptide of human HAVCR2

Full name:

hepatitis A virus cellular receptor 2

Synonyms:

TIM3; CD366; KIM-3; TIMD3; Tim-3; TIMD-3; HAVcr-2

SwissProt:

Q8TDQ0

ELISA Recommended dilution:

5000-10000

IHC positive control:

Human gastric cancer

IHC Recommend dilution:

10-50