Background:

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains two tandem Src homology-2 domains, which function as phospho-tyrosine binding domains and mediate the interaction of this PTP with its substrates. This PTP is widely expressed in most tissues and plays a regulatory role in various cell signaling events that are important for a diversity of cell functions, such as mitogenic activation, metabolic control, transcription regulation, and cell migration. Mutations in this gene are a cause of Noonan syndrome as well as acute myeloid leukemia. Two transcript variants encoding different isoforms have been found for this gene.

Applications:

ELISA, WB

Name of antibody:

PTPN11

Immunogen:

Fusion protein of human PTPN11

Full name:

protein tyrosine phosphatase, non-receptor type 11

Synonyms：

CFC, NS1, SHP2, BPTP3, PTP2C, PTP-1D, SH-PTP2, SH-PTP3

SwissProt:

Q06124

ELISA Recommended dilution:

1000-5000

WB Predicted band size:

68 kDa

WB Positive control:

NIH/3T3 cells

WB Recommended dilution:

200-1000