Background:

This gene is a member of the Rab family of small G proteins and plays a role in regulating membrane trafficking between trans-Golgi network (TGN) and recycling endosomes (RE). The encoded protein is involved in the assembly of tight junctions, which are components of the apical junctional complex (AJC) of epithelial cells. The AJC plays a role in forming a barrier between luminal contents and the underlying tissue. Additional functions associated with the protein include endocytic recycling of occludin, regulation of epithelial cell scattering, neuronal regeneration and regulation of neurite outgrowth. Alternately spliced transcript variants have been observed for this gene. A pseudogene associated with this gene is located on chromosome 12.

Applications:

ELISA, IHC

Name of antibody:

RAB13

Immunogen:

Fusion protein of human RAB13

Full name:

RAB13, member RAS oncogene family

Synonyms:

GIG4

SwissProt:

P51153

ELISA Recommended dilution:

5000-10000

IHC positive control:

Human tonsil and Human lung cancer

IHC Recommend dilution:

50-200