英文名稱: Anti-RAC2 rabbit polyclonal antibody
別 名: RAC2; EN-7; Gx; HSPC022
相關類別: 一抗
儲 存: 冷凍(-20℃) 避光
宿 主: Rabbit
抗 原: RAC2
反應種屬: Human, Mouse, Rat
標 記 物: Unconjugate
克隆類型: rabbit polyclonal
技術規格
Background: |
Rac and Cdc42 are members of the Rho-GTPase family. In mammals, Rac exists as three isoforms, Rac1, Rac2 and Rac3, which are highly similar in sequence. Rac1 and Cdc42, the most widely studied of this group, are ubiquitously expressed. Rac2 is expressed in cells of hematopoietic origin, and Rac3, while highly expressed in brain, is also found in many other tissues. Rac and Cdc42 play key signaling roles in cytoskeletal reorganization, membrane trafficking, transcriptional regulation, cell growth and development. GTP binding stimulates the activity of Rac/Cdc42, and the hydrolysis of GTP to GDP through the protein's intrinsic GTPase activity, rendering it inactive. GTP hydrolysis is aided by GTPase activating proteins (GAPs), while exchange of GDP for GTP is facilitated by guanine nucleotide exchange factors (GEFs). Another level of regulation is achieved through the binding of RhoGDI, a guanine nucleotide dissociation inhibitor, which retains Rho family GTPases, including Rac and Cdc42, in their inactive GDP-bound state. |
Applications: |
WB |
Name of antibody: |
RAC2 |
Immunogen: |
Fusion protein of human RAC2 |
Full name: |
ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2) |
Synonyms: |
RAC2; EN-7; Gx; HSPC022 |
SwissProt: |
P15153 |
WB Predicted band size: |
21 kDa |
WB Positive control: |
Jurkat and HL60 cells |
WB Recommended dilution: |
500-2000 |