Background:

The protein encoded by this gene is highly similar to S. cerevisiae DNA damage repair protein Rad18. Yeast Rad18 functions through its interaction with Rad6, which is an ubiquitin-conjugating enzyme required for post-replication repair of damaged DNA. Similar to its yeast counterpart, this protein is able to interact with the human homolog of yeast Rad6 protein through a conserved ring-finger motif. Mutation of this motif results in defective replication of UV-damaged DNA and hypersensitivity to multiple mutagens.

Applications:

WB

Name of antibody:

RAD18

Immunogen:

Synthesized peptide derived from internal of human RAD18.

Full name:

RAD18 E3 ubiquitin protein ligase

Synonyms：

RNF73

SwissProt:

Q9NS91

WB Predicted band size:

56 kDa

WB Positive control:

LOVO cells, HepG2 cells and K562 cells lysates

WB Recommended dilution:

500-3000