Background:

Members of the RAS (see HRAS; MIM 190020) subfamily of GTPases function in signal transduction as GTP/GDP-regulated switches that cycle between inactive GDP- and active GTP-bound states. Guanine nucleotide exchange factors (GEFs), such as RAPGEF5, serve as RAS activators by promoting acquisition of GTP to maintain the active GTP-bound state and are the key link between cell surface receptors and RAS activation (Rebhun et al., 2000 [PubMed 10934204])

Applications:

WB

Name of antibody:

RAPGEF5

Immunogen:

Synthesized peptide derived from internal of human RAPGEF5.

Full name:

Rap guanine nucleotide exchange factor (GEF) 5

Synonyms：

GFR; REPAC; MR-GEF

SwissProt:

Q92565

WB Predicted band size:

68 kDa

WB Positive control:

RAW264.7 cells lysate

WB Recommended dilution:

500-3000