Background:

The protein encoded by this gene interacts with calcineurin A and inhibits calcineurin-dependent signaling pathways, possibly affecting central nervous system development. This gene is located in the minimal candidate region for the Down syndrome phenotype, and is overexpressed in the brain of Down syndrome fetuses. Chronic overexpression of this gene may lead to neurofibrillary tangles such as those associated with Alzheimer disease. Three transcript variants encoding three different isoforms have been found for this gene.

Applications:

ELISA, WB, IHC

Name of antibody:

RCAN1

Immunogen:

Synthetic peptide of human RCAN1

Full name:

regulator of calcineurin 1

Synonyms：

CSP1; DSC1; RCN1; DSCR1; MCIP1; ADAPT78

SwissProt:

P53805

ELISA Recommended dilution:

2000-5000

IHC positive control:

Human liver cancer and Human brain

IHC Recommend dilution:

50-200

WB Predicted band size:

28 kDa

WB Positive control:

Mouse heart and brain tissue

WB Recommended dilution:

500-2000