Background:

NF-kappa-B is a ubiquitous transcription factor involved in several biological processes. It is held in the cytoplasm in an inactive state by specific inhibitors. Upon degradation of the inhibitor, NF-kappa-B moves to the nucleus and activates transcription of specific genes. NF-kappa-B is composed of NFKB1 or NFKB2 bound to either REL, RELA, or RELB. The most abundant form of NF-kappa-B is NFKB1 complexed with the product of this gene, RELA. Four transcript variants encoding different isoforms have been found for this gene.

Applications:

WB, IHC

Name of antibody:

RELA(Ab-311)

Immunogen:

Peptide sequence around aa.309~313 (F-K-S-I-M) derived from Human RELA.

Full name:

v-rel avian reticuloendotheliosis viral oncogene homolog A

Synonyms:

p65; NFKB3

SwissProt:

Q04206

IHC positive control:

Human breast carcinoma tissue

IHC Recommend dilution:

50-100

WB Predicted band size:

60 kDa

WB Positive control:

Hela and HL60 cell lysates

WB Recommended dilution:

500-1000