Background:

This gene encodes a large secreted extracellular matrix protein thought to control cell-cell interactions critical for cell positioning and neuronal migration during brain development. This protein may be involved in schizophrenia, autism, bipolar disorder, major depression and in migration defects associated with temporal lobe epilepsy. Mutations of this gene are associated with autosomal recessive lissencephaly with cerebellar hypoplasia. Two transcript variants encoding distinct isoforms have been identified for this gene. Other transcript variants have been described but their full length nature has not been determined.

Applications:

ELISA, IHC

Name of antibody:

RELN

Immunogen:

Synthetic peptide of human RELN

Full name:

reelin

Synonyms:

RL; ETL7; LIS2; PRO1598

SwissProt:

P78509

ELISA Recommended dilution:

5000-10000

IHC positive control:

Human colorectal cancer

IHC Recommend dilution:

25-50