Background:

Renin catalyzes the first step in the activation pathway of angiotensinogen--a cascade that can result in aldosterone release,vasoconstriction, and increase in blood pressure. Renin, an aspartyl protease, cleaves angiotensinogen to form angiotensin I, which is converted to angiotensin II by angiotensin I converting enzyme, an important regulator of blood pressure and electrolyte balance. Transcript variants that encode different protein isoforms and that arise from alternative splicing and the use of alternative promoters have been described, but their full-length nature has not been determined.

Applications:

ELISA, IHC

Name of antibody:

REN

Immunogen:

Fusion protein of human REN

Full name:

renin

Synonyms：

HNFJ2

SwissProt:

P00797

ELISA Recommended dilution:

1000-5000

IHC positive control:

Human cervical cancer and Human thyroid cancer

IHC Recommend dilution:

50-200