Background:

This gene encodes a transcriptional repressor that represses neuronal genes in non-neuronal tissues. It is a member of the Kruppel-type zinc finger transcription factor family. It represses transcription by binding a DNA sequence element called the neuron-restrictive silencer element. The protein is also found in undifferentiated neuronal progenitor cells and it is thought that this repressor may act as a master negative regular of neurogenesis. Alternatively spliced transcript variants have been described.

Applications:

ELISA, IHC

Name of antibody:

REST

Immunogen:

Synthetic peptide of human REST

Full name:

RE1 silencing transcription factor

Synonyms:

WT6; XBR; NRSF

SwissProt:

Q13127

ELISA Recommended dilution:

5000-10000

IHC positive control:

Human ovarian cancer

IHC Recommend dilution:

30-150